Document Details
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Document Type |
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Article In Journal |
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Document Title |
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Synthesis and spectroscopic studies of levofloxacin uni-dentate complexes of Ru(II), Pt(IV) and Ir(III): Third generation of quinolone antibiotic drug complexes Synthesis and spectroscopic studies of levofloxacin uni-dentate complexes of Ru(II), Pt(IV) and Ir(III): Third generation of quinolone antibiotic drug complexes |
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Document Language |
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English |
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Abstract |
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The monobasic unidentate levofloxacin (LEV; (S)-9-fluoro-2,3-dihydro-3-methy1-10-(4-methylpiperazin-1-y1)7-oxo-7H-pyrido[1,2,3-de]-1,4 benzoxazine-6-carboxylic acid) complexes of Ru(III), Pt(IV) and Ir(III) were prepared and well discussed using elemental analyses (CHN), molar conductance, infrared, electronic, effective magnetic moment, H-1-NMR, X-ray powder diffraction, scanning electron microscopy, transmittance electron microscopy and thermogravimetric (TG/DTG) analyses. The IR and electronic spectra of LEV complexes with their assignments were discussed in details which were confirmed that LEV is binding to the metal ions as a neutral unidentate ligand through the nitrogen atom of 4-methylpiperazin-1-yl moiety. The molar ratio of Ru(III) and Ir(III) chelates is 1:3 (Metal: LEV), while Pt(IV) complex has a 1:2 M ratio. The general formulas of LEV complexes have been designed as [M(L)(n)(Cl)(x)]center dot yH(2)O ( (1) M = Ru3+, L: LEV, n = 3,x = 3,y = 8; (2)M= Pt4+ L: LEV, n = 2, x = 4,y = 4 and (3) M = Ir3+, L: LEV, n = 3, x = 3,y = 6. The X-ray powder diffraction was used as technique to estimate the particle size of LEV complexes. Thermogravimetric analysis (TG-DTG) was utilized to identify the presence of coordinated, uncoordinated water molecules, mass losses and residual products |
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ISSN |
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0167-7322 |
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Journal Name |
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JOURNAL OF MOLECULAR LIQUIDS |
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Volume |
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224 |
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Issue Number |
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224 |
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Publishing Year |
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1437 AH
2016 AD |
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Article Type |
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Article |
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Added Date |
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Sunday, July 30, 2017 |
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Researchers
| M Alghamdi | Alghamdi, M | Researcher | | |
| A Alsibaai | Alsibaai, A | Researcher | | |
| M Shahawi | Shahawi, M | Researcher | | |
| M Refat | Refat, M | Researcher | | |
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