Document Details

Document Type : Article In Journal 
Document Title :
Ultrastructural studies on the changes induced by toxic effect of Doxorubicin on rat hepatocyte and protective role of Dexrazoxane
Ultrastructural studies on the changes induced by toxic effect of Doxorubicin on rat hepatocyte and protective role of Dexrazoxane
 
Subject : Biological 
Document Language : English 
Abstract : The anthracycline antibiotic Doxorubicin is one of the most effective antitumour agents used to treat human malignancies. Long term treatment with DOX is limited by its hepatotoxicity. The purpose of the present investigation was to evaluate the hepatotoxic effect of the drug when used alone or combined with the iron-chelating agent Dexrazoxane (DXZ) as protective effect. Twenty four adult male rats were divided into 3 groups: Control group, group2A, Doxorubicin 1 week (DOX 1 wk), group2B, Doxorubicin 2 weeks (DOX 2wk) and group3, Doxorubicin +Dexrazoxane (DOX+DXZ 1 wk. and 2 wk.). Ultrastructural damage showed hepatocytes injury after 1 week and more severed after 2 wk as Hepatocyte cell appears with vacuolated with damage mitochondria structures and vacuolated in nucleus. Liver cell disappear some cytoplasm organelles such as rough endoplasmic reticulum, smooth endoplasmic reticulum and lysosomes. 
ISSN : 0973-1245 
Journal Name : Biosciences Biotechnology Research Asia, Volume 5, Issue 2, December 2008, Pages 551-557 
Volume : 5 
Issue Number : 2008 
Publishing Year : 2008 AH
2008 AD 
Number Of Pages : 7 
Article Type : Article 
Added Date : Thursday, October 15, 2009 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
أسامة عبد الله حسين أبو زنادةOsama A. H. Abu ZinadahResearcherDoctorateoaboznada@kau.edu.sa
Abdu, S.B.SAbdu, S.B.SResearcherDoctorate 

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